It is available in an inhalable form that may help reduce excess mucus. Treating lung conditions and excess mucusįor people with chronic lung conditions, such as bronchitis or cystic fibrosis, some doctors recommend NAC. A doctor can provide advice about using NAC to supplement traditional treatment. Instead, a person should rely upon evidence-based treatments, such as therapy and medication, when applicable. While research into NAC as a means of relieving psychiatric symptoms may be promising, most doctors would not recommend it as a sole treatment. Increasing the amount of NAC in the body may boost levels of some neurotransmitters, which may improve a person’s mental function.Īccording to a 2018 review, NAC may also help alleviate symptoms of various psychiatric conditions, including:

Some research indicates that NAC supplementation may help in the following ways: Treating psychiatric conditions

Better risk stratification of patients taking paracetamol overdose may allow higher dose NAC and adjunctive treatments such as CYP2E1 inhibition and extracorporeal removal of paracetamol to be targeted to those patients at the highest risk of hepatotoxicity after a large paracetamol overdose.Researchers have investigated the potential for NAC to help treat a wide variety of health issues. A small study in patients with paracetamol overdoses of 40 g or more and paracetamol concentrations above the 300 mg/L nomogram line showed that modification of the standard NAC regimen to provide a total of 400–500 mg/kg NAC over 21–22 h may reduce the risk of hepatotoxicity (peak ALT > 1000 IU/L) but the impact on development of hepatic failure, liver transplantation and mortality with this approach is presently unknown. The evidence from cohorts of patients treated with the standard NAC regimen after large paracetamol overdoses shows that it is effective in most patients.

High dose acetylcysteine (NAC) has been proposed in patients taking large paracetamol overdoses based on reports of hepatotoxicity despite early initiation of NAC treatment with the commonly used 300 mg/kg intravenous acetylcysteine regimen. Paracetamol overdose is common in developed countries but less than 10% involve large ingestions exceeding 30 g or 500 mg/kg.

Nac antidote